![]() The substituted thiophenes and condensed thiophenes possess pharmacological activities like antiviral, antibacterial, anticancerous, antifungal, analgesic and anti-inflammatory activities. Findings showed that in going from the ground to the n- π* excited state the dipole moment of pyridine changed by -2.3 D, pyridazine changed by -2.0 D and pyrimidine changed by -2.1 D.Įxperimentally obtained values for dipole moment changes for pyridine was -3.2D, and -2.84 D and -2.7 D for pyridazine, and pyrimidine, respectively, following the corresponding π- π* excitation. calculated the dipole moment of the ground and lowest singlet π - π* and n- π* excited states of biologically important azines, pyrimidines, and purines. The experimentally measured dipole moment value of the only known 2-fluorocholestanone was 4.39D in the benzene solution. The calculated dipole moment of the 2α-fluorocholestanone was 4.28D and for 2β-fluorocholestanone, the value was 2.95D. calculated the dipole moment of 2-fluorocholestanone. Studies showed that the biological activity of steroids is increased by the substitution of fluorine for hydrogen on a carbon atom adjacent to a carbonyl group. The reduction in dipole moment observed due to the formation of a pyrrolidone dimer, a value of 2.2 D reported in dimer in benzene at 25°. Earlier than that, Devoto observed a much lower value of 2.3 D for pyrrolidone in benzene. ![]() calculated a lower value of 3.55 D for 2-pyrrolidone in benzene at 25°. Fischer reported a dipole moment value of 3.7 D for 2-pyrrolidone in benzene. observed dipole moment of range 3.7-3.9 D in simple amides in dioxane at 30°. Several studies had been performed to calculate the dipole moment of the five-membered lactams, the 2-Pyrrolidone. The dipole moment values of numerous compounds and their implications on biological activity are discussed here based upon the available data.Ģ-Pyrrolidone is a compound consist of five-membered l actam. Dipoles are characterized by their dipole moment (µ), a measure of the system's overall polarity, a vector quantity. ![]() The dipole is basically a system comprising of two poles, opposite in nature. ![]()
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